Chiral HPLC method for chiral purity determination of paroxetine drug substance | Zendy

Zukowski Janusz | Zendy; Brightwell Malcolm | Zendy; de Biasi Vern | Zendy

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Chiral HPLC method for chiral purity determination of paroxetine drug substance

Author(s) -

Zukowski Janusz,

Brightwell Malcolm,

de Biasi Vern

Publication year - 2003

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.10250

Subject(s) - chemistry , paroxetine , chromatography , high performance liquid chromatography , drug , chiral derivatizing agent , chiral column chromatography , chiral stationary phase , pharmacology , biochemistry , serotonin , medicine , receptor

This article describes a chiral HPLC method for (+) trans isomer of paroxetine in a paroxetine drug substance. The method development was performed to establish a suitable HPLC system in order to separate both enantiomers. It was found that a system based on a Chiralpak AD column was suitable for the analysis. Proper column maintenance and the optimized eluent composition allowed good reproducibility and sensitivity for the method. The method was also checked on a number of different columns using different HPLC equipment and gave both reproducible chromatography and reproducible quantitative results. Chirality 15:600–604, 2003. © 2003 Wiley‐Liss, Inc.

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