Simultaneous analysis of enantiomeric composition of amino acids and  N ‐acetyl‐amino acids by enantioselective chromatography | Zendy

Yu YiPing | Zendy; Wu ShihHsiung | Zendy

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Simultaneous analysis of enantiomeric composition of amino acids and N ‐acetyl‐amino acids by enantioselective chromatography

Author(s) -

Yu YiPing,

Wu ShihHsiung

Publication year - 2001

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.1024

Subject(s) - chemistry , amino acid , enantiomer , enantioselective synthesis , glycopeptide , enantiomeric excess , chiral column chromatography , high performance liquid chromatography , chromatography , stereochemistry , organic chemistry , catalysis , biochemistry , antibiotics

Among the three chiral columns, CHIROBIOTIC T™, CHIRLPAK WH, and CHIRALCEL OD‐R, tested for the separation of racemic amino acids and N ‐acetyl‐amino acids, only CHIROBIOTIC T™ chiral column which is based on covalently bonded amphoteric glycopeptide, teicoplanin, as the stationary phase ligand could be successfully developed to enantiomerically separate racemic amino acids and N ‐acetyl amino acids simultaneously. This method can be used to determine the enantiomeric composition of amino acids and N ‐acetyl‐amino acids in the catalysis of D‐aminoacylase or L‐aminoacylase and the conversion rate of N ‐acylamino acid racemases. Chirality 13:231–235, 2001. © 2001 Wiley‐Liss, Inc.

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