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Enantioresolution and absolute configurations of chiral meta ‐substituted diphenylmethanols as determined by x‐ray crystallographic and 1 H NMR anisotropy methods
Author(s) -
Kosaka Masashi,
Sugito Takeo,
Kasai Yusuke,
Kuwahara Shunsuke,
Watanabe Masataka,
Harada Nobuyuki,
Job Gabriel E.,
Shvet Alex,
Pirkle William H.
Publication year - 2003
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.10209
Subject(s) - enantiopure drug , chemistry , phthalic acid , anisotropy , crystallography , x ray , absolute configuration , diastereomer , stereochemistry , organic chemistry , enantioselective synthesis , catalysis , physics , quantum mechanics
meta ‐Substituted diphenylmethanols were enantioresolved by the method of chiral phthalic acid yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X‐ray crystallography of chiral phthalate esters and/or by the 1 H NMR anisotropy method using 2‐methoxy‐2‐(1‐naphthyl)propionic acid. Chirality 15:324–328, 2003. © 2003 Wiley‐Liss, Inc.