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Circular dichroism and the interactions of water soluble porphyrins with DNA—A minireview
Author(s) -
Pasternack Robert F.
Publication year - 2003
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.10206
Subject(s) - chemistry , porphyrin , circular dichroism , dna , nucleic acid , intercalation (chemistry) , characterization (materials science) , crystallography , stereochemistry , nanotechnology , photochemistry , biochemistry , organic chemistry , materials science
The size, sign, and profile of induced circular dichroism (CD) features in the Soret region are reliable indicators of the binding modes of porphyrins and metalloporphyrins to DNA. Porphyrins shown (using such CD criteria) to be intercalators in monodispersed DNA duplexes prove extremely useful for the detection and characterization of organized, condensed forms of nucleic acids (ψ‐condensates). In addition, certain select porphyrin derivatives can form extended assemblies on nonaggregated DNA templates. A combination of CD and resonance light scattering (RLS) measurements allows for sensitive detection and characterization of these porphyrin arrays. Chirality 15:329–332, 2003. © 2003 Wiley‐Liss, Inc.