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Nonlinearity in optical resolution via distillation applying mixtures of resolving agents
Author(s) -
Markovits Imre,
Egri Gabriella,
Fogassy Elemér
Publication year - 2002
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.10122
Subject(s) - chemistry , resolution (logic) , distillation , selectivity , chirality (physics) , tartaric acid , enantiomer , nonlinear optical , crystallization , nonlinear system , combinatorial chemistry , chromatography , biological system , organic chemistry , artificial intelligence , catalysis , chiral symmetry breaking , physics , quantum mechanics , computer science , nambu–jona lasinio model , citric acid , quark , biology
During an optical resolution it is the resolving agent that has the strongest influence on the outcome of the process. Applying a mixture of resolving agents can result either in antagonism or in synergy. We found that using mixtures of tartaric acid and its derivatives chiral selectivity is at least the same, but in several cases markedly better (synergistic effect), than the sum of the effect of the individual resolving agents. Thus, the “Dutch method,” reported for the crystallization method, also works for distillation. A calculation method is applied for measuring the synergistic effect. Interestingly, an individually inactive resolving agent can be a useful contributor to the mixture of the resolving agents. Chirality 14:674–676, 2002. © 2002 Wiley‐Liss, Inc.