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Effective enzymatic resolution of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol, precursor of fenfluramine
Author(s) -
D'Antoicola,
Mangiafico Sebastiano,
Nicolosi Giovanni
Publication year - 2002
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.10072
Subject(s) - chemistry , enantioselective synthesis , enantiomer , candida antarctica , fenfluramine , enzyme , stereochemistry , organic chemistry , lipase , catalysis , biochemistry , receptor , serotonin
Lipases from Candida antarctica and from Mucor miehei efficiently catalyze the enantioselective esterification of rac ‐1‐(3‐trifluoromethylphenyl)propan‐2‐ol. The obtained enantioforms are suitable to prepare both enantiomers of fenfluramine. Chirality 14:325–328, 2002. © 2002 Wiley‐Liss, Inc.