Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism | Zendy

Dyatkin Alexey B. | Zendy; Freedman Teresa B. | Zendy; Cao Xiaolin | Zendy; Dukor Rina K. | Zendy; Maryanoff Bruce E. | Zendy; Maryanoff Cynthia A. | Zendy; Matthews Jay M. | Zendy; Shah Rekha D. | Zendy; Nafie Laurence A. | Zendy

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Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism

Author(s) -

Dyatkin Alexey B.,

Freedman Teresa B.,

Cao Xiaolin,

Dukor Rina K.,

Maryanoff Bruce E.,

Maryanoff Cynthia A.,

Matthews Jay M.,

Shah Rekha D.,

Nafie Laurence A.

Publication year - 2002

Publication title -

chirality

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.43

H-Index - 77

eISSN - 1520-636X

pISSN - 0899-0042

DOI - 10.1002/chir.10058

Subject(s) - chemistry , tricyclic , absolute configuration , vibrational circular dichroism , component (thermodynamics) , circular dichroism , antagonist , stereochemistry , vasopressin , vasopressin receptor , receptor , biochemistry , endocrinology , physics , thermodynamics , medicine

We present the results of a study using vibrational circular dichroism (VCD) for (+)‐ 1 , which furnished an unambiguous determination of its absolute configuration as S . The most abundant conformation of (+)‐ 1 in CDCl 3 solution was also established. Chirality 14:215–219, 2002. © 2002 Wiley‐Liss, Inc.

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