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Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism
Author(s) -
Dyatkin Alexey B.,
Freedman Teresa B.,
Cao Xiaolin,
Dukor Rina K.,
Maryanoff Bruce E.,
Maryanoff Cynthia A.,
Matthews Jay M.,
Shah Rekha D.,
Nafie Laurence A.
Publication year - 2002
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.10058
Subject(s) - chemistry , tricyclic , absolute configuration , vibrational circular dichroism , component (thermodynamics) , circular dichroism , antagonist , stereochemistry , vasopressin , vasopressin receptor , receptor , biochemistry , endocrinology , physics , thermodynamics , medicine
We present the results of a study using vibrational circular dichroism (VCD) for (+)‐ 1 , which furnished an unambiguous determination of its absolute configuration as S . The most abundant conformation of (+)‐ 1 in CDCl 3 solution was also established. Chirality 14:215–219, 2002. © 2002 Wiley‐Liss, Inc.