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Inside Back Cover: Fabrication of Highly Stable Glyco‐Gold Nanoparticles and Development of a Glyco‐Gold Nanoparticle‐Based Oriented Immobilized Antibody Microarray for Lectin (GOAL) Assay (Chem. Eur. J. 10/2015)
Author(s) -
Huang LiDe,
Adak Avijit K.,
Yu ChingChing,
Hsiao WeiChen,
Lin HongJyune,
Chen MuLin,
Lin ChunCheng
Publication year - 2015
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.403479
Subject(s) - glycan , colloidal gold , chemistry , linker , lectin , nanoparticle , naked eye , combinatorial chemistry , adsorption , chromatography , nanotechnology , biochemistry , glycoprotein , detection limit , organic chemistry , materials science , computer science , operating system
Aqueous dispersions of multivalent glyco–gold nanoparticles featuring mixed thiolated ligands, glycan and an amphiphilic linker are not only stable at high ionic strength, but are also highly resistant to nonspecific protein adsorption. These features establish a simple but powerful lectin sensing strategy for probing the binding of glycans to proteins on boronic acid‐derivatized surfaces, namely the GOAL assay that permits nanomolar level detection of model plant lectins by the naked eye. For more details, see the Full Paper by C.‐C. Lin et al. on page 3956 ff.