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Frontispiece: Emerging Trends in Fluorescence Bioimaging of Divalent Metal Cations Using Small‐Molecule Indicators
Author(s) -
Liu Mingqiao,
Zhang Junwei,
Chen Zhixing
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202284562
Subject(s) - fluorescence , divalent , small molecule , nanotechnology , chemistry , biocompatible material , biophysics , computer science , materials science , biology , optics , physics , biochemistry , engineering , organic chemistry , biomedical engineering
Three new trends in fluorescence bioimaging of divalent metal cations using small‐molecule indicators have been highlighted in this concept article by Liu, Zhang and Chen on page 17ff: Red‐shifted indicators dwelling in the under‐used far‐red and NIR channels for multiplexed imaging; hybrid indicators combining the superior optical properties of synthetic dyes and the targetability of proteins; and biocompatible indicators under strong illumination lights in long term recording. These trends fall in line with the new initiative of “4D cellular physiology” which marked a grand vision of biological research in the era of big data.