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Protonated Porphyrins: Bifunctional Catalysts for the Metal‐Free Synthesis of N ‐Alkyl‐Oxazolidinones
Author(s) -
Cavalleri Matteo,
Damiano Caterina,
Manca Gabriele,
Gallo Emma
Publication year - 2023
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202202729
Subject(s) - protonation , bifunctional , porphyrin , cycloaddition , catalysis , chemistry , alkyl , yield (engineering) , combinatorial chemistry , metal , lewis acids and bases , organic chemistry , polymer chemistry , materials science , ion , metallurgy
The protonation of commercially available porphyrin ligands yields a class of bifunctional catalysts able to promote the synthesis of N ‐alkyl oxazolidinones by CO 2 cycloaddition to corresponding aziridines. The catalytic system does not require the presence of any Lewis base or additive, and shows interesting features both in terms of cost effectiveness and eco‐compatibility. The metal‐free methodology is active even with a low catalytic loading of 1 % mol, and the chemical stability of the protonated porphyrin allowed it to be recycled three times without any decrease in performance. In addition, a DFT study was performed in order to suggest how a simple protonated porphyrin can mediate CO 2 cycloaddition to aziridines to yield oxazolidinones.