Premium
An Iodide‐Mediated Anodic Amide Coupling
Author(s) -
Großmann Luca Marius,
Beier Vera,
Duttenhofer Lea,
Lennartz Laura,
Opatz Till
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202201768
Subject(s) - reagent , amide , combinatorial chemistry , iodide , chemistry , functional group , electrochemistry , organic chemistry , electrode , polymer
The ubiquity of amide bonds, present in natural products and common pharmaceuticals renders this functional group one of the most prevalent in organic chemistry. Despite its importance and a wide variety of existing methods for its formation, the latter still can be a challenge for classical activating reagents such as chloridating agents or carbodiimides. As the spent reagents often cannot be recycled, the development of more sustainable methods is highly desirable. Herein, we report an operationally simple and mild indirect electrochemical protocol to effect the condensation of carboxylic acids with amines, forming a wide variety of carboxamides.