Premium
Para ‐Fluorination of Anilides Using Electrochemically Generated Hypervalent Iodoarenes
Author(s) -
Berger Michael,
Lenhard Marola S.,
Waldvogel Siegfried R.
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202201029
Subject(s) - hypervalent molecule , electrochemistry , fluoride , chemistry , electrolyte , combinatorial chemistry , organic chemistry , inorganic chemistry , electrode , reagent
Abstract The para ‐selective fluorination reaction of anilides using electrochemically generated hypervalent ArIF 2 is reported, with Et 3 N ⋅ 5HF serving as fluoride source and as supporting electrolyte. This electrochemical reaction is characterized by a simple set‐up, easy scalability and affords a broad variety of fluorinated anilides from easily accessible anilides in good yields up to 86 %.