Cover Feature: Diarylcuprates for Selective Syntheses of Multifunctionalized Ketones from Thioesters under Mild Conditions (Chem. Eur. J. 26/2022) | Zendy

Kato Daiki | Zendy; Murase Tomoya | Zendy; Talode Jalindar | Zendy; Nagae Haruki | Zendy; Tsurugi Hayato | Zendy; Seki Masahiko | Zendy; Mashima Kazushi | Zendy

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Cover Feature: Diarylcuprates for Selective Syntheses of Multifunctionalized Ketones from Thioesters under Mild Conditions (Chem. Eur. J. 26/2022)

Author(s) -

Kato Daiki,

Murase Tomoya,

Talode Jalindar,

Nagae Haruki,

Tsurugi Hayato,

Seki Masahiko,

Mashima Kazushi

Publication year - 2022

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202201013

Subject(s) - thioester , reagent , ketone , chemistry , grignard reagent , combinatorial chemistry , copper , canagliflozin , organic chemistry , enzyme , medicine , diabetes mellitus , type 2 diabetes , endocrinology

The synthesis of ketone as a synthetic intermediate of canagliflozin from a gluconolactone‐derived thioester and a Grignard reagent with the aid of copper is likened to making Taiyaki, a Japanese fish‐shaped waffle with sweet red bean inside. The thioester (sweet red beans) and the Grignard reagent (waffle batter) are baked on a copper waffle iron to get the desired ketone as Taiyaki. More information can be found in the Research Article by H. Tsurugi, M. Seki, K. Mashima, and co‐workers (DOI: 10.1002/chem.202200474).

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