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Cover Feature: Diarylcuprates for Selective Syntheses of Multifunctionalized Ketones from Thioesters under Mild Conditions (Chem. Eur. J. 26/2022)
Author(s) -
Kato Daiki,
Murase Tomoya,
Talode Jalindar,
Nagae Haruki,
Tsurugi Hayato,
Seki Masahiko,
Mashima Kazushi
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202201013
Subject(s) - thioester , reagent , ketone , chemistry , grignard reagent , combinatorial chemistry , copper , canagliflozin , organic chemistry , enzyme , medicine , diabetes mellitus , type 2 diabetes , endocrinology
The synthesis of ketone as a synthetic intermediate of canagliflozin from a gluconolactone‐derived thioester and a Grignard reagent with the aid of copper is likened to making Taiyaki, a Japanese fish‐shaped waffle with sweet red bean inside. The thioester (sweet red beans) and the Grignard reagent (waffle batter) are baked on a copper waffle iron to get the desired ketone as Taiyaki. More information can be found in the Research Article by H. Tsurugi, M. Seki, K. Mashima, and co‐workers (DOI: 10.1002/chem.202200474).