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A Route to Lipid ALC‐0315: a Key Component of a COVID‐19 mRNA Vaccine
Author(s) -
Saadati Fariba,
Cammarone Silvia,
Ciufolini Marco A.
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202200906
Subject(s) - covid-19 , key (lock) , yield (engineering) , component (thermodynamics) , sequence (biology) , virology , computer science , computational biology , chemistry , medicine , biology , physics , biochemistry , computer security , disease , thermodynamics , infectious disease (medical specialty)
This paper describes a synthesis of ALC‐0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent