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Synergistic Strategies in Aminocatalysis
Author(s) -
Del Vecchio Antonio,
Sinibaldi Arianna,
Nori Valeria,
Giorgianni Giuliana,
Di Carmine Graziano,
Pesciaioli Fabio
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202200818
Subject(s) - nucleophile , electrophile , catalysis , chemistry , combinatorial chemistry , stereoselectivity , nanotechnology , organic chemistry , materials science
Synergistic catalysis offers the unique possibility of simultaneous activation of both the nucleophile and the electrophile in a reaction. A requirement for this strategy is the stability of the active species towards the reaction conditions and the two concerted catalytic cycles. Since the beginning of the century, aminocatalysis has been established as a platform for the stereoselective activation of carbonyl compounds through HOMO‐raising or LUMO‐lowering. The burgeoning era of aminocatalysis has been driven by a deep understanding of these activation and stereoinduction modes, thanks to the introduction of versatile and privileged chiral amines. The aim of this review is to cover recent developments in synergistic strategies involving aminocatalysis in combination with organo‐, metal‐, photo‐, and electro‐catalysis, focusing on the evolution of privileged aminocatalysts architectures.