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Nickel and Copper Catalyzed ipso ‐Phosphonodifluoromethylation of Arylboronic Acids with BrCF 2 P(O)(OEt) 2 for the Synthesis of Phosphonodifluoromethylarenes
Author(s) -
Knieb Alexander,
Krishnamurti Vinayak,
IspizuaRodriguez Xanath,
Surya Prakash G. K.
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202200457
Subject(s) - nickel , catalysis , copper , palladium , chemistry , combinatorial chemistry , transition metal , organic chemistry
A convenient method for the direct ipso‐phosphonodifluoromethylation of arylboronic acids via nickel‐copper co‐catalysis is disclosed. This work, which utilizes inexpensive first row transition metals, represents a facile alternative to the traditional palladium catalyzed approach. The method utilizes inexpensive commodity chemicals and substrates while tolerating a variety of biologically relevant functional groups. Structurally diverse phosphonodifluoromethylarenes are furnished in good yields under short reaction times. Control experiments to probe possible reaction pathways are also included.