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Dynamic Amino Acid Side‐Chains Grafting on Folded Peptide Backbone **
Author(s) -
Zagiel Benjamin,
Peker Taleen,
Marquant Rodrigue,
Cazals Guillaume,
Webb Gabrielle,
Miclet Emeric,
Bich Claudia,
Sachon Emmanuelle,
Moumné Roba
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202200454
Subject(s) - side chain , peptide , amino acid , combinatorial chemistry , chemistry , grafting , selection (genetic algorithm) , computational biology , computer science , stereochemistry , biochemistry , biology , polymer , organic chemistry , artificial intelligence
An efficient strategy for the synthesis of large libraries of conformationally defined peptides is reported, using dynamic combinatorial chemistry as a tool to graft amino acid side chains on a well‐ordered 3D (3‐dimension) peptide backbone. Combining rationally designed scaffolds with combinatorial side chains selection represents an alternative method to access peptide libraries for structures that are not genetically encodable. This method would allow a breakthrough for the discovery of protein mimetic for unconventional targets for which little is known.