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Cover Feature: Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers (Chem. Eur. J. 12/2022)
Author(s) -
Mironov Vladimir,
Shchugoreva Irina A.,
Artyushenko Polina V.,
Morozov Dmitry,
Borbone Nicola,
Oliviero Giorgia,
Zamay Tatia.,
Moryachkov Roman V.,
Kolovskaya Olga S.,
Lukyanenko Kirill A.,
Song Yanling,
Merkuleva Iuliia A.,
Zabluda Vladimir N.,
Peters Georgy,
Koroleva Lyudmila S.,
Veprintsev Dmitry V.,
Glazyrin Yury E.,
Volosnikova Ekaterina A.,
Belenkaya Svetlana V.,
Esina Tatiana I.,
Isaeva Anastasiya A.,
Nesmeyanova Valentina S.,
Shanshin Daniil V.,
Berlina An.,
Komova Nadezhda S.,
Svetlichnyi Valery A.,
Silnikov Vladimir N.,
Shcherbakov Dmitriy N.,
Zamay Galina S.,
Zamay Sergey S.,
Smolyarova Tatyana,
Tikhonova Elena P.,
Chen Kelvin H.C.,
Jeng USer,
Condorelli Gerolama,
Franciscis Vittorio,
Groenhof Gerrit,
Yang Chaoyong,
Moskovsky Alexander A.,
Fedorov Dmitri G.,
Tomilin Felix N.,
Tan Weihong,
Alexeev Yuri,
Berezovski Maxim V.,
Kichkailo Anna S.
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202200378
Subject(s) - aptamer , in silico , computational biology , fluorescence anisotropy , chemistry , biophysics , nanotechnology , biology , microbiology and biotechnology , materials science , biochemistry , gene , membrane
Digital drug design reveals DNA aptamers binding SARS‐CoV‐2 : A hybrid in silico et vitro approach, structure and interaction‐based drug design, has been developed to create highly specific DNA aptamers for the receptor‐binding domain of the SARS‐CoV‐2 spike protein. The structure and binding affinity of the aptamers were validated by small‐angle X‐ray scattering, flow cytometry, and fluorescence polarization. This approach offers a blueprint for the straightforward design of targeting molecules for new pathogens and emerging variants. More information can be found in the Research Article by Y. Alexeev, M. V. Berezovski, A. S. Kichkailo, et al. (DOI: 10.1002/chem.202104481).