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Cover Feature: Formation of Supramolecular Nanostructures through in Situ Self‐Assembly and Post‐Assembly Modification of a Biocatalytically Constructed Dipeptide Hydrazide (Chem. Eur. J. 8/2022)
Author(s) -
Shintani Yuki,
Ohtomi Taku,
Shibata Aya,
Kitamura Yoshiaki,
Hirosawa Koichiro M.,
Suzuki Kenichi G. N.,
Ikeda Masato
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202200250
Subject(s) - supramolecular chemistry , hydrazide , self assembly , dipeptide , chemistry , aqueous solution , supramolecular assembly , thermolysin , combinatorial chemistry , nanotechnology , stereochemistry , peptide , materials science , crystallography , organic chemistry , crystal structure , biochemistry , trypsin , enzyme
Thermolysin‐assisted biocatalytic construction of a self‐assembling dipeptide hydrazide from two kinds of non‐self‐assembling amino acid derivatives gives rise to the formation of supramolecular helical architectures under aqueous conditions. In addition, post‐assembly modification based on hydrazone formation allows the in‐situ constructed supramolecular helical architectures to be decorated with tethering hydrazide groups as chemical handles. More information can be found in the Research Article by M. Ikeda et al. (DOI: 10.1002/chem.202104421).