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Peptide‐Catalyzed Stereoselective Conjugate Addition Reaction of Aldehydes to C ‐Substituted Maleimides
Author(s) -
Vastakaite Greta,
Grünenfelder Claudio E.,
Wennemers Helma
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202200215
Subject(s) - succinimides , maleimide , chemistry , succinimide , stereoselectivity , conjugate , catalysis , imide , stereocenter , yield (engineering) , organic chemistry , combinatorial chemistry , enantioselective synthesis , mathematical analysis , materials science , mathematics , metallurgy
Catalytic stereoselective additions with maleimides are useful one‐step reactions to yield chiral succinimides, molecules that are widespread among therapeutically active compounds but challenging to prepare when the maleimide is C‐substituted. We present the tripeptide H‐Pro‐Pro‐Asp‐NHC 12 H 25 as a catalyst for conjugate addition reactions between aldehydes and C‐substituted maleimides to form succinimides with three contiguous stereogenic centers in high yields and stereoselectivities. The peptidic catalyst is so chemoselective that no protecting group is needed at the imide nitrogen of the maleimides. Derivatization of the succinimides was straightforward and provided access to chiral pyrrolidines, lactones, and lactams. Kinetic studies, including a Hammett plot, provided detailed insight into the reaction mechanism.