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Frontispiece: Reductive Aldol‐type Reactions in the Synthesis of Pharmaceuticals
Author(s) -
Runikhina Sofiya,
Eremin Dmitry,
Chusov Denis
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202186262
Subject(s) - aldol reaction , retrosynthetic analysis , stereoselectivity , alkylation , chemistry , combinatorial chemistry , organic chemistry , total synthesis , catalysis
The aldol‐type reaction became one of the forefathers of C−C bond formation reactions. Advancements in the synthetic methodology resulted in the development of chemo‐, regio‐, and stereoselective processes. This Review focuses on reductive aldol‐type alkylation methods implemented to the synthesis of ten approved drug substances. Furthermore, retrosynthetic analysis demonstrates that other active pharmaceutical ingredients could be obtained via reductive Aldol‐type reactions. For more information, see the Review by S. Runikhina et al. on page 15327 ff.