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Frontispiece: Molecular Recognition of Nerve Agents and Their Organophosphorus Surrogates: Toward Supramolecular Scavengers and Catalysts
Author(s) -
Finnegan Tyler J.,
Gunawardana Vageesha W. Liyana,
Badjić Jovica D.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202185361
Subject(s) - nerve agent , supramolecular chemistry , realm , chemistry , isolation (microbiology) , nanotechnology , biology , bioinformatics , political science , biochemistry , materials science , organic chemistry , crystal structure , law , acetylcholinesterase , enzyme
The extreme toxicity and rapid action of organophosphorus (OP) containing nerve agents and pesticides make them a vital target for the development of antidotes and prophylactics. In this review on page 13280 ff., J. D. Badjić and colleagues explore the realm of abiotic hosts in the sequestration and isolation of these potent toxins. A variety of the molecular hosts that have shown to bind and deactivate OPs, as well provide strategies for their design, are highlighted. Hopefully, this review inspires others in the community to create novel tools to combat the threat of OPs.