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Frontispiece: Polymer Nanodiscs and Their Bioanalytical Potential
Author(s) -
Farrelly Michelle D.,
Martin Lisandra L.,
Thang San H.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202185161
Subject(s) - polymer , biomolecule , nanotechnology , bioanalysis , amphiphile , rational design , scope (computer science) , copolymer , chemistry , materials science , combinatorial chemistry , computer science , organic chemistry , programming language
Synthetic polymer nanodiscs, structures that arise from amphipathic copolymers that capture membrane proteins (MPs) and surrounding phospholipids, offer a convenient detergent‐free solution to the challenges associated with MP purification and analysis. Thereby they help to further our understanding of MP structure and activity and so aid rational drug design. For more information on the scope of possible analytical applications of polymer nanodiscs to the study of MPs and biomolecules, see the Review by M. D. Farrelly, L. L. Martin and S. H. Thang on page 12922 ff.