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Frontispiece: Organocatalytic Strategies for the Development of the Enantioselective Inverse‐electron‐demand Hetero‐Diels‐Alder Reaction
Author(s) -
LainaMartín Víctor,
FernándezSalas Jose A.,
Alemán José
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202184962
Subject(s) - enantioselective synthesis , diels–alder reaction , organocatalysis , inverse , chemistry , catalysis , organic chemistry , combinatorial chemistry , mathematics , geometry
Inverse‐electron‐demand hetero‐Diels‐Alder reactions have been an important breakthrough for the synthesis of heterocyclic compounds. Among all their variants, the organocatalytic enantioselective version has been widely explored since the asymmetric construction of diversely functionalized scaffolds under reaction conditions encompassed within the green chemistry field is of great interest. A profound revision on the latest advances on the organocatalytic asymmetric inverse‐electron demand hetero‐Diels‐Alder reaction is shown, showing in detail the mode of action of the organocatalysts. For more information, see the Minireview by J. Alemán et al. on page 12509.