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Frontispiece: Biological and Medical Applications of Calcium Phosphate Nanoparticles
Author(s) -
Sokolova Viktoriya,
Epple Matthias
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202182761
Subject(s) - nanoparticle , calcium , surface modification , drug delivery , nucleic acid , nanotechnology , phosphate , degradation (telecommunications) , chemistry , materials science , biochemistry , combinatorial chemistry , computer science , organic chemistry , telecommunications
Among inorganic materials , calcium phosphate nanoparticles are well suited to transport organic or biological molecules into cells and tissue. They are well tolerated by cells and organisms and have a clearly defined degradation pathway, also due to their almost ubiquitous presence in the body. If they are used as carriers, they are advantageous to encapsulate sensitive cargo like proteins or nucleic acids inside to protect them from enzymatic degradation, something that is impossible with solid nanoparticles. Promising applications are seen in drug and gene delivery and also in immunization, for example, for vaccination. This Review explores the synthesis, characterization, functionalization and biomedical applications of calcium phosphate nanoparticles from the literature. For more information, see the Review article by. M. Epple and V. Sokolova on on page 7471 ff.