Premium
Frontispiece: Natural and Synthetic Oligoarylamides: Privileged Structures for Medical Applications
Author(s) -
Seedorf Tim,
Kirschning Andreas,
Solga Danny
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202182661
Subject(s) - nucleic acid , natural (archaeology) , netropsin , stereochemistry , chemistry , polymer science , biochemistry , biology , dna , paleontology , minor groove
A hitherto overlooked group of privileged substructures, namely aromatic oligoamides, for which there are natural models in the form of cystobactamids, albicidin, distamycin A, netropsin, and others is presented. These aromatic oligoamides have been employed to inhibit protein–protein and nucleic acid–protein interactions. Read more in the Review by A. Kirschning et al. on page 7321 ff.