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Frontispiece: Mimicking Biological Recognition: Lessons in Binding Hydrophilic Guests in Water
Author(s) -
Ferguson Johns Hannah P.,
Harrison Emily E.,
Stingley Kyla J.,
Waters Marcey L.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202182262
Subject(s) - supramolecular chemistry , nucleotide , molecular recognition , covalent bond , perspective (graphical) , chemistry , computational biology , molecule , combinatorial chemistry , binding site , amino acid , selectivity , receptor , binding selectivity , biochemistry , nanotechnology , computer science , biology , gene , materials science , organic chemistry , artificial intelligence , catalysis
Binding hydrophilic guests : This Review highlights strategies that have been developed in the field of supramolecular chemistry to selectively and non‐covalently bind three classes of biologically relevant molecules: nucleotides, carbohydrates, and amino acids. As several groups have systematically modified receptors for a specific guest, an evolutionary perspective is also provided in some cases. Trends in the most effective binding forces for each class are described, providing insight into selectivity and potential directions for future work. For more details see the Review by M. L. Waters on page 6620.