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Frontispiece: Synthetic Processes toward Nitriles without the Use of Cyanide: A Biocatalytic Concept Based on Dehydration of Aldoximes in Water
Author(s) -
Hinzmann Alessa,
Betke Tobias,
Asano Yasuhisa,
Gröger Harald
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202181761
Subject(s) - nitrile , cyanide , dehydration , chemistry , organic chemistry , biocatalysis , combinatorial chemistry , catalysis , reaction mechanism , biochemistry
Nitriles represent a class of compound that still raises challenges in terms of an efficient, cost‐effective, general and, at the same time, sustainable way for their synthesis. Complementing existing chemical routes, recently a cyanide‐free enzymatic process technology based on the use of an aldoxime dehydratase (Oxd) as a biocatalyst component has been developed and successfully applied for the preparation of a range of nitrile products. In these biotransformations, the Oxd enzymes catalyze the dehydration of aldoximes as readily available substrates to the desired nitrile products. Here, these developments with such enzymes are summarized, with a strong focus on synthetic applications. For more details see the Concept by H. Gröger et al. on page 5313.