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Frontispiece: A Survey of Strain‐Promoted Azide–Alkyne Cycloaddition in Polymer Chemistry
Author(s) -
Li Kelvin,
Fong Darryl,
Meichsner Eric,
Adronov Alex
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202181661
Subject(s) - bioorthogonal chemistry , cycloaddition , azide , alkyne , click chemistry , chemistry , polymer , combinatorial chemistry , molecule , organic chemistry , catalysis
Plugged in : Efficient reactions that enable the assembly of molecules into complex structures have driven extensive progress in synthetic chemistry, particularly those that occur under mild conditions and in benign solvents while producing no by‐products and that rapidly reach completion. Amongst these, the strain‐promoted azide–alkyne cycloaddition, involving various cyclooctyne derivatives reacting with azide‐bearing molecules, has gained extensive popularity in organic synthesis and bioorthogonal chemistry. This reaction has also gained momentum in polymer chemistry, where it has been used to decorate, link, crosslink, and even prepare polymer chains. Read more about key achievements in the use of this reaction to produce a variety of polymeric constructs for disparate applications in the Review by A. Adronov et al. on page 5057.