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Frontispiece: The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm
Author(s) -
Anderson Brooke A.,
Fauché Kévin,
Karunakaran Suneesh C.,
Yerabolu Jayasudhan R.,
Hud Nicholas V.,
Krishnamurthy Ramanarayanan
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202181263
Subject(s) - cyanuric acid , nucleic acid , rna , helicene , hydrogen bond , chemistry , ribose , base pair , stereochemistry , crystallography , molecule , biochemistry , dna , organic chemistry , enzyme , melamine , gene
Elementary my dear Helicene : An old‐school plastic molecular model of the supramolecular assembly formed by poly‐adenosine with cyanuric acid reveals a non‐planar spiral helicene structure, held together by alternating Watson‐Crick and Hoogsteen hydrogen bonds. In silico molecular model dynamic simulations provide further support suggesting that the helicene structure can accommodate a dyad and/or triad of poly‐A strands. The findings have implications for the role of small molecules in nucleic acid‐structural reorganization and pre‐RNA world paradigms. For more detail see the Full Paper by R. Krishnamurthy et al. on page 4033 ff.