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Frontispiece: Synthesis of Ajoene Analogues by Novel Synthetic Strategies
Author(s) -
Yamamoto Raynbird Marina,
Khokhar Shaista S.,
Neef Daniel,
Evans Gareth J. S.,
Wirth Thomas
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202180963
Subject(s) - allium sativum , ingredient , chemistry , biological activity , traditional medicine , biology , biochemistry , botany , food science , in vitro , medicine
Garlic ( Allium sativum ) has a long history as a food ingredient and traditional medicine, and garlic extracts have been known for a very long time to exhibit a wide range of biological properties (some general structures of ajoene analogues are shown on the picture of the plant). In their Full Paper on page 3008, Wirth et al. describe the synthesis of three non‐natural Allium analogues. These analogues were biologically evaluated in their ability to inhibit biofilm production in S. Aureus and P . Aeruginosa with promising results.