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Frontispiece: Cyclic Peptides as Drugs for Intracellular Targets: The Next Frontier in Peptide Therapeutic Development
Author(s) -
Buckton Laura K.,
Rahimi Marwa N.,
McAlpine Shelli R.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202180561
Subject(s) - cell permeability , cyclic peptide , intracellular , peptide , cell , chemistry , computational biology , microbiology and biotechnology , biochemistry , biophysics , biology
In their review article on page 1487, S. R. McAlpine et al., describe recent strategies used to develop cell permeable cyclic peptides that retain binding to their biological target once inside the cell. They discuss chemical strategies that have produced molecules with improved cell permeability however negatively impact biological activity. They also highlight the most promising approach involving side chain alterations.