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Frontispiece: Escaping from Flatland: Stereoconvergent Synthesis of Three‐Dimensional Scaffolds via Ruthenium(II)‐Catalyzed Noyori–Ikariya Transfer Hydrogenation
Author(s) -
Cotman Andrej Emanuel
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202180162
Subject(s) - enantiopure drug , ruthenium , transfer hydrogenation , drug discovery , enantioselective synthesis , combinatorial chemistry , noyori asymmetric hydrogenation , catalysis , planar , chemistry , nanotechnology , organic chemistry , computer science , materials science , biochemistry , computer graphics (images)
The aim of this Review is to showcase the availability of three‐dimensional scaffolds and homochiral lead‐like compounds via asymmetric transfer hydrogenation with ruthenium catalysis and inspire their direct use in drug discovery endeavors. Basic mechanistic insights are provided to demystify the stereo‐chemical outcomes, as well as examples of diastereoselective transformations of enantiopure alcohols to give a feeling of how these rigid non‐planar molecules can be further elaborated. For more information, see the Review by A. Cotman on page 39.