Premium
Cover Feature: Acid‐Catalyzed RNA‐Oligomerization from 3’,5’‐cGMP (Chem. Eur. J. 70/2021)
Author(s) -
Wunnava Sreekar,
Dirscherl Christina F.,
Výravský Jakub,
Kovařík Aleš,
Matyášek Roman,
Šponer Jiří,
Braun Dieter,
Šponer Judit E.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202104216
Subject(s) - monomer , phosphodiester bond , chemistry , steric effects , supramolecular chemistry , guanosine , rna , oligonucleotide , crystallization , catalysis , intramolecular force , nucleotide , intermolecular force , stereochemistry , molecule , combinatorial chemistry , polymer chemistry , biochemistry , organic chemistry , polymer , gene
Heat, protons and a dry crystalline material are the three prerequisites for oligonucleotide synthesis from acid‐form 3′,5′‐cyclic guanosine monophosphate monomers. The process is believed to play a role in the abiotic generation of the most ancient RNA molecules on our planet. Now, we show that the reaction is acid‐catalyzed and that the facile crystallization of the monomers is enabled by their distinctly low solubility. The highly ordered supramolecular architecture present in the monomer crystals provides ideal steric conditions for the formation of intermolecular phosphodiester linkages between the cyclic nucleotide units. More information can be found in the Research Article by D. Braun, J. E. Šponer et al. (DOI: 10.1002/chem.202103672).