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Direct Addition of Grignard Reagents to Aliphatic Carboxylic Acids Enabled by Bulky turbo ‐Organomagnesium Anilides
Author(s) -
Colas Kilian,
V. D. dos Santos A. Catarina,
Kohlhepp Stefanie V.,
Mendoza Abraham
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202104053
Subject(s) - reagent , chemistry , aryl , aniline , combinatorial chemistry , organic chemistry , alkyl , carboxylic acid , grignard reagent
The synthesis of ketones through addition of organometallic reagents to aliphatic carboxylic acids is a straightforward strategy that is limited to organolithium reagents. More desirable Grignard reagents can be activated and controlled with a bulky aniline‐derived turbo ‐Hauser base. This operationally simple procedure allows the straightforward preparation of a variety of aliphatic and perfluoroalkyl ketones alike from functionalized alkyl, aryl and heteroaryl Grignard reagents.