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Cover Feature: Structure and Biosynthesis of Myxofacyclines: Unique Myxobacterial Polyketides Featuring Varing and Rare Heterocycles [] (Chem. Eur. J. 67/2021)
Author(s) -
Popoff Alexander,
Hug Joachim J.,
Walesch Sebastian,
Garcia Ronald,
Keller Lena,
Müller Rolf
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202104027
Subject(s) - myxobacteria , biosynthesis , heterologous expression , natural product , mutagenesis , stereochemistry , chemistry , polyketide , computational biology , gene , heterologous , biology , biochemistry , genetics , mutation , bacteria , recombinant dna
Myxobacteria are not only known for their complex “social behavior” including the formation of fruiting bodies, but also for being a prolific source of natural products. We describe the discovery and isolation of the myxofacycline natural product family, which feature either an isoxazole, a 4‐pyrimidinole or a 1,2‐dihydropyrrol‐3‐one heterocycle. Intriguingly, mutagenesis of the producer strain and heterologous expression of the identified biosynthetic genes revealed that all three heterocycles originate from the same biosynthetic pathway, thus suggesting an unique biochemistry to synthesize (secondary) metabolites with exceptional scaffolds and heterocycles. More information can be found in the Full Paper by R. Müller et al. (DOI: 10.1002/chem.202103095).