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Cover Feature: Fast and Efficient Postsynthetic DNA Labeling in Cells by Means of Strain‐Promoted Sydnone‐Alkyne Cycloadditions (Chem. Eur. J. 65/2021)
Author(s) -
Krell Katja,
Pfeuffer Bastian,
Rönicke Franziska,
Chinoy Zoeisha S.,
Favre Camille,
Friscourt Frédéric,
Wagenknecht HansAchim
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103947
Subject(s) - bioorthogonal chemistry , sydnone , dna , chemistry , hela , alkyne , cover (algebra) , front cover , combinatorial chemistry , in vitro , click chemistry , biochemistry , organic chemistry , catalysis , ring (chemistry) , mechanical engineering , engineering
DNA strands , modified with the novel bioorthogonal reporter sydnone, undergo fast and efficient labeling with cyclooctyne–dye conjugates, both in vitro and in HeLa cells. These results show that sydnones are versatile bioorthogonal tags and have the premise to become essential tools for tracking DNA and potentially RNA in living cells. More information can be found in the Communication by F. Friscourt, H.‐A. Wagenknecht et al. (DOI: 10.1002/chem.202103026).