Rhoda‐Electrocatalyzed C−H Methylation and Paired Electrocatalyzed C−H Ethylation and Propylation | Zendy

Kuciński Krzysztof | Zendy; Simon Hendrik | Zendy; Ackermann Lutz | Zendy

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Rhoda‐Electrocatalyzed C−H Methylation and Paired Electrocatalyzed C−H Ethylation and Propylation

Author(s) -

Kuciński Krzysztof,

Simon Hendrik,

Ackermann Lutz

Publication year - 2022

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202103837

Subject(s) - alkylation , chemistry , combinatorial chemistry , catalysis , electrolysis , electrocatalyst , solvent , methylation , environmentally friendly , organic chemistry , biochemistry , dna , biology , ecology , electrode , electrolyte , electrochemistry

The use of electricity over traditional stoichiometric oxidants is a promising strategy for sustainable molecular assembly. Herein, we describe the rhoda‐electrocatalyzed C−H activation/alkylation of several N ‐heteroarenes. This catalytic approach has been successfully applied to several arenes, including biologically relevant purines, diazepam, and amino acids. The versatile C−H alkylation featured water as a co‐solvent and user‐friendly trifluoroborates as alkylating agents. Finally, the rhoda‐electrocatalysis with unsaturated organotrifluoroborates proceeded by paired electrolysis.

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