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Cover Feature: Additive and Emergent Catalytic Properties of Dimeric Unnatural Amino Acid Derivatives: Aldol and Conjugate Additions (Chem. Eur. J. 63/2021)
Author(s) -
Gracia Retamosa María,
RuizOlalla Andrea,
Agirre Maddalen,
Cózar Abel,
Bello Tamara,
Cossío Fernando P.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103752
Subject(s) - aldol reaction , monomer , chemistry , conjugate , catalysis , organocatalysis , combinatorial chemistry , dimer , stereochemistry , amino acid , organic chemistry , enantioselective synthesis , polymer , biochemistry , mathematics , mathematical analysis
Dimeric unnatural prolines can show emergent catalytic properties with respect to their monomeric analogues. When aldol reactions are studied, both monomeric and dimeric organocatalysts behave similarly, the stereocontrol shown by the dimers being additive with respect to their monomeric components. However, the ability of the dimers to promote Michael reactions constitutes a catalytic property not shown by the constituent monomers. This cover represents the emergent catalytic properties of this kind of unnatural γ‐dipeptides. More information can be found in the Full Paper by F. P. Cossío et al. (DOI: 10.1002/chem.202102394).