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Cover Feature: Nanoparticles for Triple Drug Release for Combined Chemo‐ and Photodynamic Therapy (Chem. Eur. J. 59/2021)
Author(s) -
MartínezEdo Gabriel,
Xue Evelyn Y.,
Ha Summer Y. Y.,
Pontón Iris,
GonzálezDelgado José Antonio,
Borrós Salvador,
Torres Tomás,
Ng Dennis K. P.,
SánchezGarcía David
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103592
Subject(s) - linker , conjugate , camptothecin , chemistry , drug delivery , doxorubicin , endocytosis , mesoporous silica , nanoparticle , ethylene glycol , combinatorial chemistry , covalent bond , biophysics , nanotechnology , materials science , biochemistry , organic chemistry , mesoporous material , medicine , mathematical analysis , mathematics , surgery , chemotherapy , biology , computer science , catalysis , cell , operating system
A pH‐responsive drug delivery system based on mesoporous silica nanoparticles (MSN) has been prepared for the delivery of three drugs with different modes of action (phthalocyanine (Pc) camptothecin (CPT) and doxorubicin (DOX)). The pores of the MSN were loaded with a photoactive conjugate formed from Pc and CPT joined by a glutathione‐sensitive linker. DOX was covalently bound to the outer surface of the MSN through a dihydrazone poly(ethylene glycol) linker. Uptake studies demonstrated proper endocytosis of the system and subsequent delivery of the three drugs into the cytoplasm and nucleus. The synergistic effect of the drugs and Pc upon light irradiation was also assessed in vitro. More information can be found in the Full Paper by T. Torres, D. K. P. Ng, D. Sánchez‐García et al. (DOI: 10.1002/chem.202101842).