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Cover Feature: Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base‐Pair Behavior: A Biophysical Analysis of dNaM‐dTPT3 (Chem. Eur. J. 56/2021)
Author(s) -
Karadeema Rebekah J.,
Morris Sydney E.,
Lairson Luke L.,
Krishnamurthy Ramanarayanan
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103397
Subject(s) - nucleic acid , alphabet , organism , base pair , computational biology , dnam , dna , transcription (linguistics) , chemistry , biology , genetics , computer science , gene , philosophy , linguistics , gene expression , dna methylation
A biophysical analysis of nucleic acid duplexes containing the unnatural hydrophobic base pair (d)NaM‐dTPT3 provides an understanding of the type of molecular level interactions that could contribute to variabilities in replication, transcription and translation in a semisynthetic organism. Such approaches could provide a basis for comprehending the behavior of other unnatural base pairs (spheres top left) with a view towards unrestricted expansion of the genetic alphabet and code (spheres bottom‐right) in a semisynthetic organism. More information can be found in the Full Paper by R. Krishnamurthy et al. (DOI: 10.1002/chem.202102348). Picture by Saurav Nagpal with the help of R.K. (background DNA image from www.canva.com).