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Front Cover: Amine‐Directed Palladium‐Catalyzed C−H Halogenation of Phenylalanine Derivatives (Chem. Eur. J. 56/2021)
Author(s) -
Ville Alexia,
Annibaletto Julien,
Coufourier Sébastien,
Hoarau Christophe,
Tamion Rodolphe,
Journot Guillaume,
Schneider Cédric,
Brière JeanFrançois
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103348
Subject(s) - halogenation , regioselectivity , palladium , chemistry , catalysis , amine gas treating , phenylalanine , halogen , combinatorial chemistry , amino acid , organic chemistry , biochemistry , alkyl
The link is shown between a pioneering chemist's questioning – drawing and sharing thoughts on a blackboard – and a solution by means of modern catalytic tools – illustrated by computer lettering. Our question was how to regioselectively introduce a halogen atom into valuable phenylalanine derivatives without using a heavy protecting group in order to rapidly construct nonproteinogenic amino acids. The proposed solution was a Pd‐catalyzed and sustainable regioselective C−H halogenation process directed by a native amine functional group. More information can be found in the Communication by G. Journot, C. Schneider, J.‐F. Brière et al. (DOI: 10.1002/chem.202102411).