Front Cover: Amine‐Directed Palladium‐Catalyzed C−H Halogenation of Phenylalanine Derivatives (Chem. Eur. J. 56/2021) | Zendy

Ville Alexia | Zendy; Annibaletto Julien | Zendy; Coufourier Sébastien | Zendy; Hoarau Christophe | Zendy; Tamion Rodolphe | Zendy; Journot Guillaume | Zendy; Schneider Cédric | Zendy; Brière JeanFrançois | Zendy

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Front Cover: Amine‐Directed Palladium‐Catalyzed C−H Halogenation of Phenylalanine Derivatives (Chem. Eur. J. 56/2021)

Author(s) -

Ville Alexia,

Annibaletto Julien,

Coufourier Sébastien,

Hoarau Christophe,

Tamion Rodolphe,

Journot Guillaume,

Schneider Cédric,

Brière JeanFrançois

Publication year - 2021

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202103348

Subject(s) - halogenation , regioselectivity , palladium , chemistry , catalysis , amine gas treating , phenylalanine , halogen , combinatorial chemistry , amino acid , organic chemistry , biochemistry , alkyl

The link is shown between a pioneering chemist's questioning – drawing and sharing thoughts on a blackboard – and a solution by means of modern catalytic tools – illustrated by computer lettering. Our question was how to regioselectively introduce a halogen atom into valuable phenylalanine derivatives without using a heavy protecting group in order to rapidly construct nonproteinogenic amino acids. The proposed solution was a Pd‐catalyzed and sustainable regioselective C−H halogenation process directed by a native amine functional group. More information can be found in the Communication by G. Journot, C. Schneider, J.‐F. Brière et al. (DOI: 10.1002/chem.202102411).

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