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Cover Feature: The Influence of Secondary Interactions on the [N−I−N] + Halogen Bond (Chem. Eur. J. 55/2021)
Author(s) -
Lindblad Sofia,
Boróka Németh Flóra,
Földes Tamás,
Heiden Daniel,
Vang Herh G.,
Driscoll Zakarias L.,
Gonnering Emily R.,
Pápai Imre,
Bowling Nathan,
Erdelyi Mate
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103250
Subject(s) - halogenation , electrophile , steric effects , halogen , chemistry , reactivity (psychology) , halogen bond , stereoselectivity , computational chemistry , medicinal chemistry , electrophilic addition , stereochemistry , organic chemistry , medicine , alkyl , alternative medicine , pathology , catalysis
A three‐center halogen bond modulates the reactivity of a halonium ion and is thereby applicable for controlling the halogenation of alkenes. Chelation, strain, steric hindrance, and electrostatic interactions influence the halonium release rate. Combined experimental and theoretical analysis of the reaction mechanism highlights the impact of secondary interactions, and is expected to provide a handle on the induction of stereoselectivity in electrophilic halogenation. More information can be found in the Full Paper by I. Pápai, N. Bowling, M. Erdelyi et al. (DOI: 10.1002/chem.202102575).