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Metal‐Catalyzed Haloalkynylation Reactions
Author(s) -
Kreuzahler Mathis,
Haberhauer Gebhard
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103046
Subject(s) - catalysis , aryne , chemistry , halogen , combinatorial chemistry , stereoselectivity , metal , organic chemistry , alkyl
Metal catalysis has revolutionized synthetic chemistry, leading to entirely new, very efficient transformations, which enable access to complex functionalized molecules. One such new transformation method is the haloalkynylation reaction, in which both a halogen atom and an alkynyl unit are transferred to an unsaturated carbon‐carbon bond. This minireview summarizes the development of metal‐catalyzed haloalkynylation reactions since their beginning about a decade ago. So far, arynes, alkenes and alkynes have been used as unsaturated systems and the reactivities of these systems are summarized in individual chapters of the minireview. Especially, the last few years have witnessed a rapid development due to gold‐catalyzed reactions. Here, we discuss how the choice of the catalytic system influences the regio‐ and stereoselectivity of the addition.