Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones | Zendy

Hilker Simon | Zendy; Posevins Daniels | Zendy; Unelius C. Rikard | Zendy; Bäckvall JanE. | Zendy

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Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones

Author(s) -

Hilker Simon,

Posevins Daniels,

Unelius C. Rikard,

Bäckvall JanE.

Publication year - 2021

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202102683

Subject(s) - transesterification , diastereomer , epimer , chemistry , candida antarctica , catalysis , lipase , enantioselective synthesis , kinetic resolution , organic chemistry , ruthenium , enzyme

Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.

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