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Chemoenzymatic Dynamic Kinetic Asymmetric Transformations of β‐Hydroxyketones
Author(s) -
Hilker Simon,
Posevins Daniels,
Unelius C. Rikard,
Bäckvall JanE.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102683
Subject(s) - transesterification , diastereomer , epimer , chemistry , candida antarctica , catalysis , lipase , enantioselective synthesis , kinetic resolution , organic chemistry , ruthenium , enzyme
Herein we report on the development and application of chemoenzymatic Dynamic Kinetic Asymmetric Transformation (DYKAT) of α‐substituted β‐hydroxyketones (β‐HKs), using Candida antartica lipase B (CALB) as transesterification catalyst and a ruthenium complex as epimerization catalyst. An operationally simple protocol allows for an efficient preparation of highly enantiomerically enriched α‐substituted β‐oxoacetates. The products were obtained in yields up to 95 % with good diastereomeric ratios.