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Continuous Flow Synthesis of [Au(NHC)(Aryl)] (NHC=N‐Heterocyclic Carbene) Complexes
Author(s) -
Cauwenbergh Thibault,
Tzouras Nikolaos V.,
Scattolin Thomas,
Bhandary Subhrajyoti,
Simoens Andreas,
Van Hecke Kristof,
Stevens Christian V.,
Nolan Steven P.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102379
Subject(s) - carbene , aryl , continuous flow , combinatorial chemistry , scalability , chemistry , catalysis , reactivity (psychology) , flow chemistry , organic chemistry , computer science , biochemical engineering , database , engineering , medicine , alkyl , alternative medicine , pathology
The use of weak and inexpensive bases has recently opened promising perspectives towards the simpler and more sustainable synthesis of Au(I)‐aryl complexes with valuable applications in catalysis, medicinal chemistry, and materials science. In recent years, continuous manufacturing has shown to be a reliable partner in establishing sustainable and controlled process scalability. Herein, the first continuous flow synthesis of a range of Au(I)‐aryl starting from widely available boronic acids and various [Au(NHC)Cl] (NHC=N‐heterocyclic carbene) complexes in unprecedentedly short reaction times and high yields is reported. Successful synthesis of previously non‐ or poorly accessible complexes exposed fascinating reactivity patterns. Via a gram‐scale synthesis, convenient process scalability of the developed protocol was showcased.