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General, Straightforward, and Atom‐Economical Synthesis of Vinyl Triflimides
Author(s) -
Hao Lei,
Pan Qianwen,
Zhang Congdi,
Wang Sen,
Wang Weilin,
Zhang Junjie,
Bai Lu,
Wang Youliang
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102369
Subject(s) - stereoselectivity , atom (system on chip) , combinatorial chemistry , reactivity (psychology) , chemistry , organic chemistry , computer science , catalysis , medicine , alternative medicine , pathology , embedded system
Vinyl triflimides were only accessible recently and their chemistry is yet to be discovered. Herein, we describe a general, straightforward and atom‐economical synthesis of these materials from alkynes and triflimide. A vast array of terminal and internal alkynes with broad spectrum of functionalities could be employed to generate various di‐ and trisubstituted vinyl triflimides regiospecifically with high to specific stereoselectivity. Moreover, the protocol could be conducted on gram scale using terminal and internal alkynes. Preliminarily attempts to probe the unprecedented reactivity of vinyl triflimides revealed part of its chemical properties.