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Front Cover: Phosphate‐Based Self‐Immolative Linkers for Tuneable Double Cargo Release (Chem. Eur. J. 50/2021)
Author(s) -
Šimon Petr,
Tichotová Markéta,
García Gallardo María,
Procházková Eliška,
Baszczyňski Ondřej
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102215
Subject(s) - front cover , phosphate , chemistry , cover (algebra) , nanotechnology , combinatorial chemistry , materials science , biochemistry , engineering , mechanical engineering
Phosphorus‐based self‐immolative linkers activated by light sequentially release two phenolic cargos. Structurally modifying the lactate spacer responsible for self‐immolation allows adjustable cargo release, ranging from minutes to days. The cargo release rate can be additionally tuned by varying the cargos. NMR spectroscopy coupled to UV light illumination enabled us to track and characterize products released during the self‐immolation process. More information can be found in the Full Paper by E. Procházková, O. Baszczyňski, et al. (DOI: 10.1002/chem.202101805).