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Cover Feature: Towards DNA‐Encoded Micellar Chemistry: DNA‐Micelle Association and Environment Sensitivity of Catalysis (Chem. Eur. J. 39/2021)
Author(s) -
Klika Škopić Mateja,
Gramse Christian,
Oliva Rosario,
Pospich Sabrina,
Neukirch Laura,
Manisegaran Magiliny,
Raunser Stefan,
Winter Roland,
Weberskirch Ralf,
Brunschweiger Andreas
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102060
Subject(s) - micelle , chemistry , amphiphile , dna , combinatorial chemistry , catalysis , aldehyde , copolymer , organic chemistry , biochemistry , polymer , aqueous solution
The development of DNA‐compatible reactions is central to advance DNA‐encoded library technology. Amphiphilic block copolymer micelles functionalized with sulfonic acid moieties assemble in water to micelles and localize the catalyst in them. DNA‐aldehyde conjugates were reacted to target heterocycles by micelle‐promoted Povarov‐ and Biginelli‐reaction with minimal DNA damage. Strikingly, DNA‐conjugates accumulated effectively in the micellar compartments as a prerequisite for compound synthesis. More information can be found in the Full Paper by R. Weberskirch, A. Brunschweiger, et al. (DOI: 10.1002/chem.202100980).