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Cover Feature: Fluorescent Indolo[3,2‐ a ]phenazines against Toxoplasma gondii : Concise Synthesis by Gold‐Catalyzed Cycloisomerization with 1,2‐Silyl Migration and ipso ‐Iodination Suzuki Sequence (Chem. Eur. J. 38/2021)
Author(s) -
Merkt Franziska K.,
Mazzone Flaminia,
Sazzadeh Shabnam Shaneh,
Bonda Lorand,
Hinz Larissa K. E.,
Gruber Irina,
Buchholz Karin,
Janiak Christoph,
Pfeffer Klaus,
Müller Thomas J. J.
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202101939
Subject(s) - toxoplasma gondii , fluorescence , cycloisomerization , substituent , chemistry , combinatorial chemistry , photochemistry , aryl , stereochemistry , catalysis , biology , organic chemistry , physics , quantum mechanics , antibody , immunology , alkyl
New superheroes in town: Fluorescent Indolo[3,2‐ a ]phenazines fight against T. gondii . Indolo[3,2‐a]phenazines are a novel type of multifunctional heterocycle. They are tunable luminophores and highly biologically active. Furthermore, their photophysical characteristics correlate with Hammett σ p+ substituent parameters allowing finetuning of excited state properties such as emission maxima, Stokes shifts, and fluorescence quantum yields, by the remote para‐ aryl substitution. Best of all, they are highly active at low concentration against medically relevant pathogens such as the Apicomplexa parasite Toxoplasma gondii with IC 50 up to 0.67±0.13μM. Therefore, these heterocyclic superheroes are promising bug fighters in novel anti‐parasitic therapies. More information can be found in the Full Paper by T. J. J. Müller et al. (DOI: 10.1002/chem.202101391).